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The first clinical
manifestations (weakness, sexual dysfunction, arthralgia, cardiac
symptoms, dyspnoea on effort) can occur after the age of 30 years in
men and 35 years in women (protected for longer by menstruation,
pregnancy and delivery).

In the absence of diagnosis, severe
complications can develop during the 5th decade: nervous breakdown,
arthropathy, heart failure, diabetes mellitus, cirrhosis with risk of
progression towards carcinoma, responsible for handicaps and premature
death.

DIAGNOSTIC ELEMENTS: The diagnosis is evoked in the case of an
increase in transferrine saturation (>45%)


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