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Re: RECOMMENDATIONS ON HOW TO KEEP YOUR ARTERIES CLEAN
>Subject: RECOMMENDATIONS ON HOW TO KEEP YOUR ARTERIES CLEAN
>From: techtrans@gmail.com
>Date: 12/27/2004 3:32 PM Mountain Standard Time
>Message-id: <1104186760.697712.257460@z14g2000cwz.googlegroups.com>
>
>I'm interested in any information I can get on how to keep your
>arteries clean.
>Or any ideas that would help reduce plaque.
>
Atherosclerosis. 1998 Sep;140(1):147-53. Related Articles, Links
Soy lecithin reduces plasma lipoprotein cholesterol and early atherogenesis in
hypercholesterolemic monkeys and hamsters: beyond linoleate.
Wilson TA, Meservey CM, Nicolosi RJ.
Center for Chronic Disease Control, Department of Health and Clinical Science,
University of Massachusetts Lowell, 01854, USA.
The current study was designed to investigate the hypocholesterolemic and
anti-atherogenic properties of soy lecithin beyond its fatty acid content. In
experiment 1, 18 cynomolgus monkeys were divided into three groups of six and
fed diets which approximated either the average American diet (AAD), the
American Heart Association (AHA) Step I diet, or a modified AHA (mAHA) Step I
diet containing 3.4% soy lecithin for 8 weeks. Plasma samples were collected
from food-deprived monkeys and analyzed for total cholesterol (TC),
high-density lipoprotein cholesterol (HDL-C), very low- and low-density
lipoprotein cholesterol (non-HDL-C), and triglyceride (TG) concentrations.
Group comparisons revealed that monkeys fed the mAHA Step 1 diet had
significantly lower plasma TC (-46%) and non-HDL-C (-55%) levels compared to
the AAD diet, whereas monkeys fed the AHA Step 1 diet had lesser reductions in
plasma TC (-21%) and non-HDL-C (-18%) levels. The monkeys fed the mAHA Step I
diet had significantly lower plasma TC (-32%) and non-HDL-C (-45%) compared to
the monkeys fed the AHA step diet. Also, only the mAHA Step I diet
significantly reduced pre-treatment plasma TC and non-HDL-C levels by - 39 and
-51% respectively with no significant effect on plasma HDL-C or TG levels. In
experiment 2, 45 hamsters were divided into three groups of 15 and fed the
following three modified non-purified diets for 8 weeks: a hypercholesterolemic
diet (HCD) containing 10%, coconut oil and 0.05%, cholesterol, HCD plus 3.4%,
soy lecithin (+SL), or the HCD with added levels of linoleate and choline
equivalent to the +SL diet but no lecithin (-SL). Plasma lipids were determined
as in experiment 1 and aortas were perfusion-fixed and Oil Red O stained for
morphometric analyses of fatty streak area. Relative to the HCD group, the
+SL-treated hamsters had significantly lower plasma TC (-58%), non-HDL-C (-73%)
and aortic fatty streak area (-90%). Relative to the -SL group, hamsters fed
the +SL diet had significantly lower plasma TC (-33%), non-HDL-C (-50%) and
significantly reduced aortic fatty streak area (-79%). In conclusion, the first
experiment suggests that the cholesterol-lowering efficacy of the AHA Step I
diet can be enhanced with the addition of soy lecithin without reducing plasma
HDL-C levels. whereas the second experiment suggest that the
hypocholesterolemic, and in particular, the anti-atherogenic properties of soy
lecithin cannot be attributed solely to its linoleate content.
PMID: 9733225 [PubMed - indexed for MEDLINE]
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